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1

An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications

Russo, Andrew T., Grosenbach, Douglas W., Chinsangaram, Jarasvech, Honeychurch, Kady M., Long, Paul G, Lovejoy, Candace, Maiti, Biswajit, Meara, Ingrid, Hruby, Dennis E.

Journal:

Expert Review of Anti-infective Therapy

Year:

2020

File:

PDF, 1.17 MB

2020

2

ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping

Duraffour, S., Lorenzo, M. M., Zoller, G., Topalis, D., Grosenbach, D., Hruby, D. E., Andrei, G., Blasco, R., Meyer, H., Snoeck, R.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

3

Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge

Russo, Andrew T., Berhanu, Aklile, Bigger, Catherine B., Prigge, Jon, Silvera, Peter M., Grosenbach, Douglas W., Hruby, Dennis

Journal:

Year:

2019

Language:

english

File:

PDF, 1.60 MB

english, 2019

4

Treatment with the Smallpox Antiviral Tecovirimat (ST-246) Alone or in Combination with ACAM2000 Vaccination Is Effective as a Postsymptomatic Therapy for Monkeypox Virus Infection

Berhanu, Aklile, Prigge, Jonathan T., Silvera, Peter M., Honeychurch, Kady M., Hruby, Dennis E., Grosenbach, Douglas W.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 986 KB

english, 2015

5

Oral Tecovirimat for the Treatment of Smallpox

Grosenbach, Douglas W., Honeychurch, Kady, Rose, Eric A., Chinsangaram, Jarasvech, Frimm, Annie, Maiti, Biswajit, Lovejoy, Candace, Meara, Ingrid, Long, Paul, Hruby, Dennis E.

Journal:

New England Journal of Medicine

Year:

2018

Language:

english

File:

PDF, 326 KB

english, 2018

6

Development of the small-molecule antiviral ST-246 ® as a smallpox therapeutic

Grosenbach, Douglas W, Jordan, Robert, Hruby, Dennis E

Journal:

Future Virology

Year:

2011

Language:

english

File:

PDF, 2.27 MB

english, 2011

7

Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge

Russo, Andrew T., Berhanu, Aklile, Bigger, Catherine B., Prigge, Jon, Silvera, Peter M., Grosenbach, Douglas W., Hruby, Dennis

Journal:

Year:

2019

File:

PDF, 1.60 MB

2019

8

Chlamydia psittaci IncA is phosphorylated by the host cell and is exposed on the cytoplasmic face of the developing inclusion

D. D. Rockey, D. Grosenbach, D. E. Hruby, M. G. Peacock, R. A. Heinzen, T. Hackstadt

Journal:

Molecular Microbiology

Year:

1997

Language:

english

File:

PDF, 401 KB

english, 1997

9

Analysis of the Site Occupancy Constraints of Primary Amino Acid Sequences in the Motif Directing Palmitylation of the Vaccinia Virus 37-kDa Envelope Protein

Scott G. Hansen, Douglas W. Grosenbach, Dennis E. Hruby

Journal:

Year:

1999

Language:

english

File:

PDF, 364 KB

english, 1999

10

Identification and Analysis of Vaccinia Virus Palmitylproteins

Douglas W. Grosenbach, Scott G. Hansen, Dennis E. Hruby

Journal:

Year:

2000

Language:

english

File:

PDF, 355 KB

english, 2000

11

Novel Small Molecule Inhibitors of Dengue Virus Replication

Chelsea Byrd, Jessica Page, Chris Harver, Doug Grosenbach, Aklile Berhanu, Dennis Hruby, Robert Jordan

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 69 KB

english, 2009

12

Small Molecule Inhibitors of Dengue Virus Replication are Active In Vivo

Chelsea Byrd, Chris Harver, Kara Cardwell, Doug Grosenbach, Aklile Berhanu, Dongcheng Dai, Dennis Hruby, Robert Jordan

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 84 KB

english, 2010

13

A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production

Douglas W. Grosenbach, Jeffrey Schlom, Linda Gritz, Alicia Gómez Yafal, James W. Hodge

Journal:

Cellular Immunology

Year:

2003

Language:

english

File:

PDF, 331 KB

english, 2003

14

Vector-based delivery of tumor-associated antigens and T-cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity

James W Hodge, Douglas W Grosenbach, Jeffrey Schlom

Journal:

Cancer Detection and Prevention

Year:

2002

Language:

english

File:

PDF, 525 KB

english, 2002

15

Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination

Douglas W. Grosenbach, Robert Jordan, David S. King, Aklile Berhanu, Travis K. Warren, Dana L. Kirkwood-Watts, Shanthakumar Tyavanagimatt, Ying Tan, Rebecca L. Wilson, Kevin F. Jones, Dennis E. Hruby

Journal:

Year:

2008

Language:

english

File:

PDF, 2.73 MB

english, 2008

16

Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice

Aklile Berhanu, David S. King, Stacie Mosier, Robert Jordan, Kevin F. Jones, Dennis E. Hruby, Douglas W. Grosenbach

Journal:

Year:

2010

Language:

english

File:

PDF, 2.06 MB

english, 2010

17

Enhancing the potency of peptide-pulsed antigen presenting cells by vector-driven hyperexpression of a triad of costimulatory molecules

James W Hodge, Douglas W Grosenbach, Ariel N Rad, Mariateresa Giuliano, Helen Sabzevari, Jeffrey Schlom

Journal:

Year:

2001

Language:

english

File:

PDF, 409 KB

english, 2001

18

Adult Attention Deficit Disorder: Introduction and case study

M.J. Grosenbach

Journal:

Journal of Bodywork and Movement Therapies

Year:

2000

Language:

english

File:

PDF, 142 KB

english, 2000

19

Adult Attention Deficit Disorder: Clinical psychology approach

M.J. Grosenbach

Journal:

Journal of Bodywork and Movement Therapies

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

20

Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase

Byrd, C. M., Grosenbach, D. W., Berhanu, A., Dai, D., Jones, K. F., Cardwell, K. B., Schneider, C., Yang, G., Tyavanagimatt, S., Harver, C., Wineinger, K. A., Page, J., Stavale, E., Stone, M. A., Full

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 873 KB

english, 2013

21

Antiviral options for biodefense

Byrd, Chelsea M, Grosenbach, Douglas W, Hruby, Dennis E

Journal:

Current Opinion in Virology

Year:

2013

Language:

english

File:

PDF, 384 KB

english, 2013

22

Clinical Safety of a Viral Vector Based Prostate Cancer Vaccine Strategy

Arlen, Philip M., Skarupa, Lisa, Pazdur, Mary, Seetharam, Mahesh, Tsang, Kwong Y., Grosenbach, Douglas W., Feldman, Jarett, Poole, Diane J., Litzinger, Mary, Steinberg, Seth M., Jones, Elizabeth, Chen

Journal:

The Journal of Urology

Year:

2007

Language:

english

File:

PDF, 78 KB

english, 2007

23

ANTIANDROGEN, VACCINE AND COMBINATION THERAPY IN PATIENTS WITH NONMETASTATIC HORMONE REFRACTORY PROSTATE CANCER

ARLEN, PHILIP M., GULLEY, JAMES L., TODD, NUSHIN, LIEBERMAN, RONALD, STEINBERG, SETH M., MORIN, STEVE, BASTIAN, ANNE, MARTE, JENNIFER, TSANG, KWONG-YOK, BEETHAM, PATRICIA, GROSENBACH, DOUGLAS W., SCHL

Journal:

The Journal of Urology

Year:

2005

Language:

english

File:

PDF, 682 KB

english, 2005

24

A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein

Byrd, C. M., Dai, D., Grosenbach, D. W., Berhanu, A., Jones, K. F., Cardwell, K. B., Schneider, C., Wineinger, K. A., Page, J. M., Harver, C., Stavale, E., Tyavanagimatt, S., Stone, M. A., Bartenschla

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 1.77 MB

english, 2013

25

IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

Litzinger, M. T., Fernando, R., Curiel, T. J., Grosenbach, D. W., Schlom, J., Palena, C.

Journal:

Year:

2007

Language:

english

File:

PDF, 999 KB

english, 2007

26

Vaccination of BALB/c Mice with Escherichia coli-Expressed Vaccinia Virus Proteins A27L, B5R, and D8L Protects Mice from Lethal Vaccinia Virus Challenge

Berhanu, A., Wilson, R. L., Kirkwood-Watts, D. L., King, D. S., Warren, T. K., Lund, S. A., Brown, L. L., Krupkin, A. K., VanderMay, E., Weimers, W., Honeychurch, K. M., Grosenbach, D. W., Jones, K. F

Journal:

Journal of Virology

Year:

2008

Language:

english

File:

PDF, 1009 KB

english, 2008

27

Palmitylation of the Vaccinia Virus 37-kDa Major Envelope Antigen: IDENTIFICATION OF A CONSERVED ACCEPTOR MOTIF AND BIOLOGICAL RELEVANCE

Grosenbach, D. W., Ulaeto, D. O., Hruby, D. E.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 849 KB

english, 1997

28

Effects of Postchallenge Administration of ST-246 on Dissemination of IHD-J-Luc Vaccinia Virus in Normal Mice and in Immune-Deficient Mice Reconstituted with T Cells

Zaitseva, M., Shotwell, E., Scott, J., Cruz, S., King, L. R., Manischewitz, J., Diaz, C. G., Jordan, R. A., Grosenbach, D. W., Golding, H.

Journal:

Journal of Virology

Year:

2013

Language:

english

File:

PDF, 3.24 MB

english, 2013

29

Appendix 4: Standing Orders of the International Labour Conference as Adopted at the Twenty-Seventh Session on 22 October 1945

Grosenbach, D. W., Berhanu, A., King, D. S., Mosier, S., Jones, K. F., Jordan, R. A., Bolken, T. C., Hruby, D. E.

Journal:

The American Journal of International Law

Year:

1947

Language:

english

File:

PDF, 410 KB

english, 1947

30

Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice

Grosenbach, D. W., Berhanu, A., King, D. S., Mosier, S., Jones, K. F., Jordan, R. A., Bolken, T. C., Hruby, D. E.

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 364 KB

english, 2010

31

Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans

Leeds, J. M., Fenneteau, F., Gosselin, N. H., Mouksassi, M.-S., Kassir, N., Marier, J. F., Chen, Y., Grosenbach, D., Frimm, A. E., Honeychurch, K. M., Chinsangaram, J., Tyavanagimatt, S. R., Hruby, D.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 602 KB

english, 2013

32

ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation

Berhanu, A., King, D. S., Mosier, S., Jordan, R., Jones, K. F., Hruby, D. E., Grosenbach, D. W.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2009

Language:

english

File:

PDF, 1.90 MB

english, 2009

33

Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox)

Mucker, E. M., Goff, A. J., Shamblin, J. D., Grosenbach, D. W., Damon, I. K., Mehal, J. M., Holman, R. C., Carroll, D., Gallardo, N., Olson, V. A., Clemmons, C. J., Hudson, P., Hruby, D. E.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 574 KB

english, 2013

34

Brefeldin A inhibits vaccinia virus envelopment but does not prevent normal processing and localization of the putative envelopment receptor P37

Ulaeto, D., Grosenbach, D., Hruby, D. E.

Journal:

Journal of General Virology

Year:

1995

Language:

english

File:

PDF, 1.52 MB

english, 1995

35

Vaccines with Enhanced Costimulation Maintain High Avidity Memory CTL

Yang, S., Hodge, J. W., Grosenbach, D. W., Schlom, J.

Journal:

The Journal of Immunology

Year:

2005

Language:

english

File:

PDF, 685 KB

english, 2005

36

TRICOM Vector Based Cancer Vaccines

Garnett, Charlie, Greiner, John, Tsang, Kwong-Yok, Kudo-Saito, Chie, Grosenbach, Douglas, Chakraborty, Mala, Gulley, James, Arlen, Philip, Schlom, Jeffrey, Hodge, James

Journal:

Current Pharmaceutical Design

Year:

2006

Language:

english

File:

PDF, 352 KB

english, 2006

37

Enhanced Activation of T Cells by Dendritic Cells Engineered to Hyperexpress a Triad of Costimulatory Molecules

Hodge, J. W., Rad, A. N., Grosenbach, D. W., Sabzevari, H., Yafal, A. G., Gritz, L., Schlom, J.

Journal:

JNCI Journal of the National Cancer Institute

Year:

2000

Language:

english

File:

PDF, 978 KB

english, 2000

38

Efficacy of ST-246 versus Lethal Poxvirus Challenge in Immunodeficient Mice

Douglas W. Grosenbach, Aklile Berhanu, David S. King, Stacie Mosier, Kevin F. Jones, Robert A. Jordan, Tove' C. Bolken, Dennis E. Hruby and Bernard Moss

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.29 MB

english, 2010

39

[Methods in Molecular Genetics] Viral Gene Techniques Volume 7 || [4] Construction and use of recombinant vaccinia virus vectors

Grosenbach, Douglas

Year:

1995

Language:

english

File:

PDF, 1.38 MB

english, 1995

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